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1,4,6-Androstatriene-3,17-dione

1,4,6-Androstatriene-3,17-dione

1,4,6-Androstatriene-3,17-dione(ATD) is a potent irreversible aromatase inhibitor that inhibits estrogen biosynthesis by permanently binding and inactivating aromatase in adipose and peripheral tissue.[1]It is used to control estrogen synthesis.[2]

ATD was present in some over-the-counterbodybuildingsupplements until 2009 as well as Topical ATD solutions that work transdermally. The product was developed and commercialized in the dietary supplement market place by industry journeyman, Bruce Kneller who holds a United States Patent for use of the compound and related compounds (#7,939,517) and Gaspari Nutrition. ATD has many names in sports supplements including: 1,4,6 etiollochan-dione, 3, 17-keto-etiochol-triene, androst-1,4,6-triene-3,17-dione and many others. These all refer to CAS# 633-35-2.

ATD may cause a positive test for the anabolic steroid boldenone, of which it is a possible metabolite and production contaminant and is also prohibited in amateur and professional sports which forbids aromatase inhibitors.[3]

A related agent is exemestane (Aromasin).

1,4,6-Androstatriene-3,17-dione
Clinical data
Pregnancy category
  • US: X (Contraindicated)
Routes of administration Oral
Legal status
Legal status
  • US: Supplement
Pharmacokinetic data
Metabolism Hepatic
Elimination half-life 48 hours
Identifiers
CAS Number
PubChemCID
ChemSpider
ChEBI
Chemical and physical data
Formula C19H22O2
Molar mass 282 g·mol−1
3D model (JSmol)
  • Interactive image[15]
(verify)[16]

References

[1]

Citation Link//www.ncbi.nlm.nih.gov/pubmed/7472286Covey, DF; Hood, WF (1981). “Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity”.Endocrinology.108(4): 1597–9. doi:10.1210/endo-108-4-1597. PMID 7472286.

Sep 21, 2019, 4:42 PM
[2]

Citation Linkwww.sciencedirect.comAdkins-Regan, Elizabeth; Cary H Leung (2006-07-06). “Sex steroids modulate changes in social and sexual preference during juvenile development in zebra finches”.Hormones and Behavior. Elsevier Inc.50(5): 772–778. doi:10.1016/j.yhbeh.2006.07.003. PMID 16919276. Archived from the original on 2013-01-04. Retrieved 2007-10-07.

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[3]

Citation Link//www.ncbi.nlm.nih.gov/pubmed/19089863Parr MK, Fusshöller G, Schlörer N, Opfermann G, Piper T, Rodchenkov G, Schänzer W (2009). “Metabolism of androsta-1,4,6-triene-3,17-dione and detection by gas chromatography/mass spectrometry in doping control”.Rapid Commun Mass Spectrom.23(2): 207–18. doi:10.1002/rcm.3861. PMID 19089863.

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[4]

Citation Linkwww.commonchemistry.org633-35-2

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[5]

Citation Linkpubchem.ncbi.nlm.nih.gov104880

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[6]

Citation Linkwww.chemspider.com94659

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[7]

Citation Linkwww.ebi.ac.ukCHEBI:131190

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[8]

Citation Linkchemapps.stolaf.eduInteractive image

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[9]

Citation Link//doi.org/10.1210%2Fjcem-59-6-108810.1210/jcem-59-6-1088

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[10]

Citation Link//www.ncbi.nlm.nih.gov/pubmed/65416586541658

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[11]

Citation Linkwww.commonchemistry.org633-35-2

Sep 21, 2019, 4:42 PM
[12]

Citation Linkpubchem.ncbi.nlm.nih.gov104880

Sep 21, 2019, 4:42 PM
[13]

Citation Linkwww.chemspider.com94659

Sep 21, 2019, 4:42 PM
[14]

Citation Linkwww.ebi.ac.ukCHEBI:131190

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[15]

Citation Linkchemapps.stolaf.eduInteractive image

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[16]

Citation Linken.wikipedia.org(verify)

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[17]

Citation Linkdoi.org10.1210/endo-108-4-1597

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[18]

Citation Linkwww.ncbi.nlm.nih.gov7472286

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[19]

Citation Linkarchive.today“Sex steroids modulate changes in social and sexual preference during juvenile development in zebra finches”

Sep 21, 2019, 4:42 PM
[20]

Citation Linkdoi.org10.1016/j.yhbeh.2006.07.003

Sep 21, 2019, 4:42 PM
[21]

Citation Linkwww.ncbi.nlm.nih.gov16919276

Sep 21, 2019, 4:42 PM
[22]

Citation Linkwww.sciencedirect.comthe original

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[23]

Citation Linkdoi.org10.1002/rcm.3861

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[24]

Citation Linkwww.ncbi.nlm.nih.gov19089863

Sep 21, 2019, 4:42 PM
[25]

Citation Linkdoi.org10.1210/jcem-59-6-1088

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[26]

Citation Linkwww.ncbi.nlm.nih.gov6541658

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[27]

Citation Linken.wikipedia.orgThe original version of this page is from Wikipedia, you can edit the page right here on Everipedia.Text is available under the Creative Commons Attribution-ShareAlike License.Additional terms may apply.See everipedia.org/everipedia-termsfor further details.Images/media credited individually (click the icon for details).

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